The film was met with negative reviews from critics, but became somewhat of a box office success.
In Pirates of the Caribbean: The Curse of the Black Pearl (2003), she played Anamaria, a female pirate who signs up to join Will Turner and Mr.
Gibbs for a chance to confront Jack Sparrow for stealing her ship.
Ese mismo año protagonizó la película dominicana La maldición del padre Cardona junto a personalidades dominicanas como Freddy Beras Goico, Milagros Germán, Raymond Pozo, Anthony Álvarez y Sergio Carlo.
Saldaña también fue la protagonista en el video para la canción de Juan Luis Guerra "La Llave De Mi Corazón", e interpretó a Uhura en la secuela de 2009 de la saga Star Trek.
Estas películas son Avatar, The Losers, y Death at a Funeral.
En agosto de 2010, se estrenó un anuncio de televisión de Saldaña para la marca Calvin Klein haciendo el debut de un producto llamado "Envy".In 2005, Saldana appeared in Constellation, Guess Who with Ashton Kutcher, and Dirty Deeds. Abrams asked Saldana to play the role because he had seen and liked her previous work.She then starred in the romantic comedy-dramas Premium in 2006 and After Sex in 2007. Saldana had never seen the original series, though she had played a Trekkie in The Terminal (2004), but agreed to play the role after Abrams complimented her.She met with Nichelle Nichols, who explained to her how she had created Uhura's background and named the character.Saldana's second high-profile film in 2009 was James Cameron's Avatar, in which she starred as the alien hunter Neytiri.As to why she never appeared in any further films in the franchise, Saldana revealed that she almost quit acting following "disrespectful treatment" on set of the film.