Both coaches achieved moderate success, but neither outlasted his contracted term: Mc Ewan resigned amid a contract dispute, Prince G."Prink" Callison, Oregon native, alumnus, former player and coach of the freshman team, took over from Spears in 1932.
Behind standout back Mike Mikulak and a smothering defense (50 points allowed, five shutouts), Callison led the 1933 Webfoots to a 9–1 mark and Pacific Coast Conference co-championship, with the only loss to USC.
This record would stand as the best in school history until 2001.
In the 1957 season Oregon tied Oregon State for the conference title, but earned the Rose Bowl bid because of the conference no-repeat rule.
The Webfoots lost 10–7 to the heavily favored and number one ranked Ohio State University in the 1958 Rose Bowl.
Braven Dyer of the Los Angeles Times, who had picked Ohio State to win by a 48–14 score, said: "The score of 10–7 was a complete moral victory for the underdog Ducks from Eugene who had been doped to lose by three touchdowns.
They lost, but at day's end there weren’t many fans who were willing to concede that the better team had won." " Vincent X.
Oregon lost the 1920 Rose Bowl to Harvard University, 7–6.
In the late 1920s and early 1930s, Oregon made the first attempts to establish a nationally prominent football program by luring established Eastern coaches west, first John "Cap" Mc Ewan in 1926 from Army, then Clarence "Doc" Spears from Minnesota in 1930.
Bezdek, Oregon's first truly professional coach, led the team from 1913 through 1917.
A versatile motivator of athletes, during his tenure Bezdek was also the West Coast scout for the Pittsburgh Pirates.
In the 1916 season, Oregon went undefeated with seven wins and one tie under Bezdek, shutting out all their opponents except California.